What is GOURI?
GOURI is a collagen-stimulating injectable made from polycaprolactone (PCL), a biodegradable medical polymer that has been used safely in medicine for many years.
Unlike traditional dermal fillers, GOURI is:
- Fully liquid (not particle-based)
- Non-volumising
- Designed to spread evenly through the skin
- Focused on tightening, firmness and skin quality, rather than shape or contour
GOURI works by stimulating fibroblasts — the cells responsible for collagen production — leading to neo-collagenesis, the gradual formation of new collagen within the skin.
How does GOURI work?
GOURI works through a biologically intelligent, four-stage process:
- Precise injection into the dermal–subcutaneous layer
The treatment is typically delivered using a cannula to allow smooth, controlled placement. - Natural distribution through the skin
Because GOURI is fully solubilised, it spreads evenly rather than sitting in isolated pockets. - Fibroblast stimulation
Polycaprolactone activates fibroblasts, triggering collagen production. - Progressive skin tightening and strengthening
Over the following weeks, collagen density, dermal thickness and elasticity increase, resulting in firmer, smoother, more resilient skin.
GOURI itself is fully biodegradable, breaking down naturally over time with no permanent residue left beneath the skin.
GOURI vs Polynucleotides vs Skin Boosters
At Mulberry House Clinic, we offer a range of injectable skin treatments. These are not competing treatments, but different tools used for different skin needs.
| Treatment Type | Best for | How it works | Longevity | Key Difference |
| GOURI (PCL collagen stimulator) | Skin laxity, loss of firmness, thinning skin | Stimulates fibroblasts to produce new collagen and increase dermal density | Long-term collagen renewal, typically 6–12 months | Strong structural collagen stimulation and skin tightening |
| Polynucleotides (PN / PDRN) | Skin repair, hydration, early ageing, delicate areas | Supports cellular repair and improves skin quality | Shorter-term, often requires courses | Focused on healing and hydration rather than tightening |
| HA Skin Boosters | Dehydrated or dull skin | Adds hydration and glow using hyaluronic acid | Temporary (weeks–months) | Improves hydration but does not stimulate collagen |
In simple terms:
- GOURI focuses on structure and firmness
- Polynucleotides focus on repair and regeneration
- Skin boosters focus on hydration and glow
Many patients benefit from a combined approach, tailored to their skin and stage of ageing.
GOURI FAQ
Frequently Asked Questions
